Modelling the suppression of autoimmunity after pathogen infection

B.M.P.M. Oliveira1, R. Trinchet A.2, A. A. Pinto3, N. J. Burroughs4

1Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Portugal; LIAAD, INESC-TEC, Porto, Portugal, 2LIAAD, INESC-TEC, Porto, Portugal; Universidade de Santiago de Compostela, Spain, 3LIAAD, INESC-TEC, Porto, Portugal; Departamento de Matemática da Faculdade de Ciências da Universidade do Porto, Portugal, 4Systems Biology Centre, University of Warwick, UK

We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukine 2 (IL-2) secretion. We model the suppression of the autoimmune line of T cells after a different line of T cells was stimulated by a pathogen infection. In this paper we show that if the population of the pathogen responding line of T cells becomes large enough, the competition for IL-2 and the increase in the death rates may lead to a depletion in the concentration of autoimmune T cells. Provided this lasts for a suffciently long time period, the concentration of autoimmune T cells can be brought down to values inside the basin of attraction of the controlled state and autoimmunity can be suppressed.

keywords: Autoimmunity suppression, T cells, Tregs, cytokines, ODE model

Poster: Modelling the suppression of autoimmunity after pathogen infection